notebook-ai-agents-skill

Create/refactor reproducible analysis notebooks with Marimo (preferred) or Jupyter (minimal support). Use for interactive, narrative-first analyses.

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Install skill "notebook-ai-agents-skill" with this command: npx skills add fmschulz/omics-skills/fmschulz-omics-skills-notebook-ai-agents-skill

Notebook AI Agents Skill (Marimo First)

Build narrative-first, reproducible notebooks with strict run-all validation and clean data loading patterns. Prefer Marimo for new notebooks; support Jupyter only when needed for existing .ipynb files.

Instructions

  1. Prefer Marimo for new work. Create a .py notebook and keep cells small and deterministic.
  2. Outline the notebook (purpose, data sources, analysis steps, outputs) before coding.
  3. Use project-relative paths and DuckDB for data loading (TSV/Parquet preferred).
  4. Build plots with the shared style rules.
  5. Validate by running the notebook end-to-end (Marimo: marimo run; Jupyter: restart kernel + run all).

Quick Reference

TaskAction
Marimo docshttps://docs.marimo.io/
Jupyter (legacy)See docs/notebook_structure.md
Pixi + Jupyter (legacy)See docs/pixi_jupyter.md
Data loadingSee docs/data_loading_duckdb.md
Plot stylingSee docs/plot_style.md
ValidationSee docs/verification.md
Templates (legacy)templates/kiss_notebook_template.py

Input Requirements

  • Notebook scope and goals
  • Data file paths (TSV/Parquet preferred)
  • Python environment (Pixi recommended)
  • Marimo installed (preferred) or Jupyter available (legacy)

Output

  • Reproducible notebook with narrative markdown
  • Validated run-all execution
  • Plots and tables suitable for reporting

Quality Gates

  • Narrative text precedes code for each major step
  • All cells run top-to-bottom without hidden state
  • Data paths are project-relative and verified
  • Plots are labeled, readable, and consistent

Examples

Example 1: Run a Marimo notebook

marimo run notebooks/analysis.py

Example 2: Execute a Jupyter notebook (legacy)

python scripts/execute_notebook.py path/to/notebook.ipynb

Troubleshooting

Issue: Marimo fails to run due to missing dependencies Solution: Install required packages in the Pixi environment and re-run.

Issue: Jupyter notebook fails on restart Solution: Remove hidden state, re-run from a clean kernel, and fix warnings.

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